Profile

  • Title:
    Assistant Professor, Biology
  • Department:
    Biology

William Schmidt

Contact

Background

Dr. William Schmidt has been part of the Biology faculty since August 2020. He earned his Ph.D. from Boston University School of Medicine in 2014 and performed his postdoctoral research at Johns Hopkins School of Medicine in the Cardiology Division. Dr. Schmidt’s research has focused on elucidating the underlying molecular mechanisms responsible for modulating skeletal and cardiac muscle contraction with a focus in understanding the mechanistic bases for pathological and disease development. Since coming to Rivier, Dr. Schmidt has pursued a passion for teaching undergraduates and has experience teaching introductory biology, human anatomy and physiology, genetics, and cell and molecular biology. He continues to pursue his research interests at Rivier University and encourages any student who might be interested in investigating molecular mechanisms related to disease to contact him directly.

Degrees

  • Ph.D., Boston University
  • B.S., Stevens Institute of Technology

Specialties

  • Molecular Physiology and Disease Mechanisms
  • Striated Muscle Physiology and Mechanics

Courses Taught

  • BIO 103 General Biology I
  • BIO 105 Anatomy and Physiology I
  • BIO 106 Anatomy and Physiology II
  • BIO 202 Genetics
  • BIO 308 Molecular Cell Biology
  • BIO 390 Seminar in Biology

Recent Publications and Proceedings

  1. Schmidt W, Madan A, Foster DB, and Cammarato A. Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity. J. Biol. Chem., 2020.
  2. Viswanathan MC*, Schmidt W*, Franz P*, Rynkiewicz MJ, Newhard CS, Madan A, Lehman W, Swank DM, Preller M, and Cammarato A. A role for actin flexibility in thin filament-mediated contractile regulation and myopathy. Nat Comm., 2020. *co-first authors
  3. Madan A, Viswanathan MC, Woulfe KC, Schmidt W, et al. TNNT2 mutations in the tropomyosin binding region of TNT1 disrupt its role in contractile inhibition and stimulate cardiac dysfunction. PNAS, 2020.
  4. Lin YH, Schmidt W, Fritz KS, Jeong MY, et al. Site-specific acetyl-mimetic modification of cardiac troponin I modulates myofilament relaxation and calcium sensitivity. JMCC, 2020.
  5. Schmidt W, and Anthony Cammarato. The Actin ‘A-Triad’s’ Role in Contractile Regulation in Health and Disease. J. of Physiol., 2019.
  6. Ren X, Schmidt W, Huang Y, Lu H, Liu W, et al. Fropofol decreases force development in cardiac muscle. FASEB J., 2018
  7. Viswanathan MC, Schmidt W, Rynkiewicz MJ, Agarwal K, Gao J, et al. Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy. Cell Rep., 2017
  8. Kooij V, Viswanathan MC, Lee DI, Rainer PP, Schmidt W, et al. Profilin Modulates Sarcomeric Organization and Mediates Cardiomyocyte Hypertrophy. Circ. Res., 2016.
  9. Schmidt WM, Lehman W, Moore JR. Direct observation of tropomyosin binding to actin filaments.  Cytoskeleton, 2015.
  10. Viswanathan MC, Blice-Baum AC, Schmidt W, Foster DB, Cammarato A. Pseudo-acetylation of K326 and K328 of actin disrupts Drosophila melanogaster indirect flight muscle structure and performance. Frontiers in Physiology, 2015.